Preclinical TSPO Ligand PET to Visualize Human Glioma Xenotransplants: A Preliminary Study
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چکیده
منابع مشابه
Preclinical TSPO Ligand PET to Visualize Human Glioma Xenotransplants: A Preliminary Study
Current positron emission tomography (PET) imaging biomarkers for detection of infiltrating gliomas are limited. Translocator protein (TSPO) is a novel and promising biomarker for glioma PET imaging. To validate TSPO as a potential target for molecular imaging of glioma, TSPO expression was assayed in a tumor microarray containing 37 high-grade (III, IV) gliomas. TSPO staining was detected in a...
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Department of Physics of Molecular Imaging Systems, Institute for Experimental Molecular Imaging, RWTH Aachen University, Aachen, Germany The combination of PET and MRI into a hybrid device is challenging since both systems might interfere with each other. Therefore, the study of the MR-compatibility of such a combined device is crucial to understand and solve potential interference phenomena. ...
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Intracerebral hemorrhage (ICH) is a devastating disease without effective treatment. After ICH, the immediate infiltration of leukocytes and activation of microglia are accompanied by a rapid up-regulation of the 18-kDa translocator protein (TSPO). TSPO ligands have shown anti-inflammatory and neuroprotective properties in models of CNS injury. In this study, we determined the impact of a TSPO ...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0141659